About Rx

Locally and seasonally inspired, ingredient-driven Southern cuisine is what we, at Rx, stand for. Opened in 2012, we are located in the historic Hall's Drug Store building nestled in the Castle Street Arts District just blocks away from Historic Downtown Wilmington. 


Whether it's Dave's pork or Stefan's heirloom tomatoes, we are excited to create dishes that highlight our region's organic farmers and fishermen. If our family of farmers is growing it, you can bet it's on our menu. That same philosophy is applied to our seasonal cocktail menu, and our extensive wine list is sure to deliver just what the doctor ordered. We proudly feature local craft beers on our rotating taps, and our walls are adorned with ever-changing works from local artists in our commission-free space. 

From the Press


Our State Magazine

“At Rx, Wilmington’s pharmacy-turned-restaurant, the atmosphere is modern, but the food philosophy is as old as Southern cooking itself.”


“Casual yet refined, with a sophisticated southern menu.”

New York Magazine


"Opened in an old drugstore in the Castle Street neighborhood, Rx has become a local favorite thanks to familiar-yet-contemporary dishes."


No Boundaries International Art Colony

A nonprofit artist residency program that provides artists from both the local community and around the world a forum for free expression and cross-cultural dialogue.



A collective of restaurant professionals and purveyors working closely to enhance the Wilmington community's culinary arts scene while supporting local charities and nonprofits.


Feast Down East

A nonprofit economic development program established in 2006 whose aim is to build a strong local food system and alleviate poverty in rural and urban communities. Feast Down East helps small scale limited-resource farmers build and sustain their farms and connect with local markets.

Oasis NC

A nonprofit organization committed to providing outstanding autism support and instructional services for individuals with autism spectrum disorder and their families in NC. 

CENC Food Bank

A nonprofit organization whose mission is to ensure that no one goes hungry in central and eastern NC. 

Frankie Lemmon School and Developmental Center

The Frankie Lemmon School and Development Center provides life-changing education and support for children with special education needs and their families, which leads to successful participation in family and community life and achievement of the child's full potential.

Good Shepherd Center

The mission of Good Shepherd Center is to feed the hungry, shelter the homeless, and foster transition to housing.

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©2017 Rx Restaraunt and Bar .

Web Design by Fred and Mina Design Co.